Publication: SDF-1 and CXCR4 in normal and malignant hematopoiesis
Authors
Juarez, J. ; Bendall, L.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Over recent years it has become apparent that
the chemokine SDF-1 and its receptor CXCR4 play
pivotal roles in normal hematopoiesis. They are essential
for the normal ontogeny of hematopoiesis during
embryogenesis and continue to play a key role in
retaining hematopoietic progenitors within the bone
marrow microenvironment in the adult. As a result of
this role disruption of SDF-1/CXCR4 interactions results
in mobilization of hematopoietic progenitors and
standard mobilization protocols disrupt this axis.
Similarly SDF-1/CXCR4 interactions are required for
homing and engraftment of hematopoietic stem cells
during transplantation. SDF-1 regulates the localisation
of leukemic cells and like their normal counterparts most
leukemic cells respond to SDF-1 with increased
adhesion, survival and proliferation. However in some
instances leukemic cell responses to SDF-1 can be
disregulated, the impact of which on the progression of
disease in not known. In this review we discuss the
pleiotropic roles of SDF-1/CXCR4 interactions in
human hematopoietic stem cell ontogeny, bone marrow
homing and engraftment, mobilization and how these
interactions impact on malignant hematopoiesis.
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