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2-Isocyanoanilines and their mono-Boc-protected derivatives

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dc.contributor.authorSaura Sanmartín, Adrián
dc.contributor.authorLópez Leonardo, Carmen
dc.contributor.authorAlajarín Cerón, Mateo
dc.contributor.departmentQuímica Orgánica
dc.contributor.otherFacultad de Química
dc.date.accessioned2025-12-12T07:51:29Z
dc.date.available2025-12-12T07:51:29Z
dc.date.copyright©2025, The Royal Society of Chemistry
dc.date.issued2025-07-15
dc.description El acceso abierto se ha financiado a través de los acuerdos transformativos
dc.description.abstractAmong the variety of synthetically useful isocyanides, 2-isocyanoanilines have been scarcely reported in the chemical literature, despite the rich chemistry that expectedly could derive from the reactivities of their two functional groups. This is the case not only for the parent compound but also for most of their N-monosubstituted derivatives. The reason behind such behavior relies upon their chemical instability, apparently attributable to the presence of the N–H bond. Among these latter species, two tert-butyl carbamates are notorious exceptions, as they have been widely utilized in multicomponent reactions but poorly described. This review covers the chemistry of these compounds from a critical perspective, analyzing the causes of the instability of these privileged molecular scaffolds, as well as highlighting the reactivity of their mono-Boc-protected derivatives.
dc.formatapplication/pdf
dc.format.extent10
dc.identifier.citationOrganic & Biomolecular Chemistry, 23, 2025, 7244-7253
dc.identifier.doihttps://doi.org/10.1039/D5OB00677E
dc.identifier.eissn1477-0539
dc.identifier.issn1477-0520
dc.identifier.urihttp://hdl.handle.net/10201/179149
dc.languageeng
dc.publisherRoyal Society of Chemistry
dc.relationThis work was supported by the MICINN (PID2020-113686GB-I00/MCIN/AEI/10.13039/501100011033) and Fundacion Seneca-CARM (Project 21907/PI/22). A. S.-S. gratefully acknowledges “la Caixa” Foundation (ID 100010434) for a fellowship (LCF/BQ/PR24/12050020).
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob00677e
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSíntesis multicomponentes
dc.subjectIsocianoanilinas
dc.subjectQuímica orgánica
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.title2-Isocyanoanilines and their mono-Boc-protected derivatives
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublication434dc353-54ab-4dcc-b277-61e489ca79d6
relation.isAuthorOfPublicationa85354de-54fb-479f-9c99-86fc40dd9268
relation.isAuthorOfPublication.latestForDiscovery8a681db2-d510-4819-9164-b21b3619dffc
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