Publication: Ligand-controlled regiodivergent catalytic amidation of unactivated secondary alkyl bromides
Authors
Tortajada, Andreu ; Menezes Correia, Jose Tiago ; Serrano, Eloisa ; Monleón, Alicia ; Tampieri, Alberto ; Day, Craig S. ; Juliá Hernández, Francisco ; Martin, Ruben
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Publisher
American Chemical Society
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DOI
https://doi.org/10.1021/acscatal.1c02913
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info:eu-repo/semantics/article
Description
© 2021 American Chemical Society. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in ACS Catalysis. To access the final edited and published work see https://doi.org/10.1021/acscatal.1c02913
Abstract
A regiodivergent Ni-catalyzed amidation of unactivated secondary alkyl bromides is described. The site-selectivity of the amidation event is dictated by subtle differences on the ligand backbone, allowing introduction of the amide function at either the original sp3 carbon−halide bond or at distal sp3 C−H sites within an alkyl side-chain via chain-walking scenarios.
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Citation
ACS Catal. 2021, 11, 10223–10227
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