Publication: Glycoprotein CD44 expression in benign, premalignant and malignant epithelial lesions of the larynx. An immunohistochemical study including
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Date
1999
Authors
Ioachim, E. ; Assimakopoulos, D. ; Goussia, A.C. ; Peschos, D. ; Skevas, A. ; Agnantis, N.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
CD44 is an integral membrane glycoprotein
that has diverse functions in cell-cell and cell-substrate
interactions. It has been suggested that it may be a
determinant of metastatic and invasive behavior in
carcinomas. The immunohistochemical expression of
CD44 was examined in a series of 34 squamous cell
carcinomas, 13 in situ carcinomas, 35 cases with various
degrees of epithelial dysplasia, 10 papillomas and 17
cases of keratosis. We used the monoclonal mouse antihuman
phagocytic glycoprotein-1 CD44 (clone DF
1485), on formalin-fixed, paraffin-embedded tissue.
CD44 expression was correlated with the expression of
Rb and p53 proteins, with the proliferative indices Ki-67
and PCNA as well as with conventional clinicopathological
data. The mean value of CD44 expression
was 78.84 in squamous cell carcinomas, 78.04 in in situ
carcinomas, 54.93 in dysplasia, 26.8 in papillomas and
24.97 in keratosis. There was no significant difference of
CD44 expression between in situ and invasive
carcinomas. However, a strong difference of reaction
between carcinomas and the other cases was observed.
CD44 expression was statistically higher in dysplastic
lesions than the cases of keratosis (p<0.0001) and
papillomas (p=0.01). In the group of invasive
carcinomas, CD44 expression was statistically correlated
with pRb (p=0.011), while in preinvasive lesions it was
correlated with PCNA (p=0.016). The relationship with
the degree of dysplasia or grade of carcinoma and p53
protein expression was insignificant.
These observations suggest that CD44 expression
may be involved in the multiple mechanism of the
development and progression of laryngeal lesions and
may help to predict the risk of transformation of the
benign or precancerous lesions to cancer.
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