Publication: Tea polyphenols, their biological effects and potential molecular targets
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Date
2008
Authors
Chen, Di ; Milacic, Vesna ; Si Chen, Marina ; Biao Wan, Sheng ; Har Lam, Wai ; Huo, Congde ; Landis-Piwowar, Kristin R. ; Cindy Cui, Qiuzhi ; Wali, Anil ; Hang Chan, Tak ; Ping Dou, Q.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Tea is the most popular beverage in the
world, second only to water. Tea contains an infusion of
the leaves from the Camellia sinensis plant rich in
polyphenolic compounds known as catechins, the most
abundant of which is (-)-EGCG. Although tea has been
consumed for centuries, it has only recently been studied
extensively as a health-promoting beverage that may act
to prevent a number of chronic diseases and cancers. The
results of several investigations indicate that green tea
consumption may be of modest benefit in reducing the
plasma concentration of cholesterol and preventing
atherosclerosis. Additionally, the cancer-preventive
effects of green tea are widely supported by results from
epidemiological, cell culture, animal and clinical studies.
In vitro cell culture studies show that tea polyphenols
potently induce apoptotic cell death and cell cycle arrest
in tumor cells but not in their normal cell counterparts.
Green tea polyphenols were shown to affect several
biological pathways, including growth factor-mediated
pathway, the mitogen-activated protein (MAP) kinasedependent
pathway, and ubiquitin/proteasome
degradation pathways. Various animal studies have
revealed that treatment with green tea inhibits tumor
incidence and multiplicity in different organ sites such as
skin, lung, liver, stomach, mammary gland and colon.
Recently, phase I and II clinical trials have been
conducted to explore the anticancer effects of green tea
in humans. A major challenge of cancer prevention is to
integrate new molecular findings into clinical practice.
Therefore, identification of more molecular targets and biomarkers for tea polyphenols is essential for
improving the design of green tea trials and will greatly
assist in a better understanding of the mechanisms
underlying its anti-cancer activity.
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