Publication: Matrix metalloproteinase stromelysin-3
in development and pathogenesis
Authors
Wei, L. ; Shi, Y.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The extracellular matrix (ECM) serves as a
medium for cell-cell interactions and can directly signal
cells through cell surface ECM receptors, such as
integrins. In addition, many growth factors and signaling
molecules are stored in the ECM. Thus, ECM
remodeling and/or degradation plays a critical role in
cell fate and behavior during many developmental and
pathological processes. ECM remodeling/degradation is,
to a large extent, mediated by matrix metalloproteinases
(MMPs), a family of extracellular or membrane-bound,
Zn2+-dependent proteases that are capable of digesting
various proteinaceous components of the ECM. Of
particular interest among them is the MMP11 or
stromelysin-3, which was first isolated as a breast cancer
associated protease. Here, we review some evidence for
the involvement of this MMP in development and
diseases with a special emphasis on amphibian
metamorphosis, a postembryonic, thyroid hormonedependent
process that transforms essentially every
organ/tissue of the animal.
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Citation
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