Publication: Expression of toll-like receptors in the human decidua
Authors
Krikun, G. ; Lockwood, C.J. ; Abrahams, V.M. ; Mor, G. ; Paidas, M. ; Guller, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Background: Successful trophoblast invasion
and transformation of the maternal spiral arteries
requires that the pregnant endometrium (i.e., decidua)
act in an immunologically paradoxical fashion,
accepting the semi-allogenic placenta, while maintaining
host defenses against an array of microbial pathogens. In
contrast to the growing evidence that the immune
surveillance molecules known as Toll-like receptors
(TLRs) are expressed by trophoblasts and fetal
membranes, to date, no studies have been conducted on
the decidua. Methods: Decidual tissues and cells were
obtained from women undergoing first trimester elective
terminations or repeat Cesarean sections and analyzed at
both the protein and mRNA level. Results: We now
demonstrate for the first time that human decidua
differentially express TLRs and their downstream
signaling molecules as well as TLR stimulated induction
of cytokine production in the first and third trimester of
pregnancy. Conclusions: These findings suggest that the
decidua is a critical component of the innate immune
response in pregnancy. Moreover, the results have
implications for the success or failure of compromised
pregnancies in early or late gestation
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