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Analysis of the anti-inflammatory potential of Brassica bioactive compounds in a human macrophage-like cell model derived from HL-60 cells

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dc.contributor.authorRuiz Alcaraz, Antonio José
dc.contributor.authorMartínez-Sanchez, María Antonia
dc.contributor.authorGarcía Peñarrubia, María del Pilar
dc.contributor.authorMartínez-Esparza Alvargonzález, María Concepción
dc.contributor.authorRamos Molina, Bruno
dc.contributor.departmentBiología Molecular B e Inmunología
dc.contributor.otherFacultad de Biología
dc.date.accessioned2026-01-12T11:16:18Z
dc.date.available2026-01-12T11:16:18Z
dc.date.copyright© 2022 Published by Elsevier Masson SAS
dc.date.issued2022-03-10
dc.description.abstractBackground: Chronic inflammatory diseases are major causes of global morbidity and mortality. Acute inflammation is meant to protect the body against foreign agents, but it also plays a major role in tissue repairment. Several mediators are involved in this process, including pro-inflammatory cytokines produced by macrophages. Occasionally, if the inflammatory response is not resolved, the acute inflammatory process can evolve into a chronic inflammation. Natural compounds from vegetables are considered as an important source of active agents with potential to treat or prevent inflammatory related pathologies and could be used as an alternative of the therapeutic agents currently in use, such as non-steroidal anti-inflammatory drugs (NSAIDs), which present several side effects. Methods: In this research work we evaluated in vitro the anti-inflammatory activity of a series of ten phytochemicals present in Brassica, measured as the potential of those compounds to reduce the production of key pro- inflammatory cytokines (TNFα, IL-6 and IL-1β) by a human macrophage-like cell model of HL-60 cells. Results: Most of the tested phytochemicals (including the most representative bioactive molecules of the major classes of compounds present in cruciferous foods such as glucosinolates, isothiocyanates, hydroxycinnamic acids, flavonols and anthocyanins) demonstrated significant anti-inflammatory activity at micromolar level in the absence of cytotoxic effects in this human macrophage-like cell model. Conclusion: These data confirm that phytochemicals commonly obtained from Brassica may be potential therapeutic leads to treat or prevent human chronic inflammation and related diseases.
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dc.format.extent12
dc.identifier.citationBiomedicine & Pharmacotherapy 149 (2022) 112804
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2022.112804
dc.identifier.eissn1950-6007
dc.identifier.issn0753-3322
dc.identifier.urihttp://hdl.handle.net/10201/185690
dc.languageeng
dc.publisherElsevier
dc.relationThis research was funded by Fundación Séneca – Murcia Regional Agency for Science and Technology (Comunidad Autónoma de la Región de Murcia, CARM), through the grant number 20855/PI/18); and, by the Institute of Health “Carlos III” (ISCIII), and co-funded by the Fondo Europeo de Desarrollo Regional-FEDER (grant number PI20/00505). M.A.M.-S was supported by a PFIS contract from the ISCIII (FI21/00003, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER). BR-M was supported by the “Miguel Servet Type I” program (CP19/00098, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER).
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0753332222001925?via%3Dihub
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBrassica
dc.subjectChronic inflammation
dc.subjectHuman macrophages
dc.subjectCytokines
dc.subjectBioactive compounds
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleAnalysis of the anti-inflammatory potential of Brassica bioactive compounds in a human macrophage-like cell model derived from HL-60 cells
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublication37ff1b37-1579-4eb9-b618-68868c3e2665
relation.isAuthorOfPublication79449fb4-f715-4255-a064-bfecc4b502de
relation.isAuthorOfPublication.latestForDiscoveryc5d54ef3-bd3b-4330-b4a1-252ab278925b
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