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The significance of M1 macrophage should be highlighted in peripheral nerve regeneration

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dc.contributor.authorFeng, Ruiqin
dc.contributor.authorZhang, Peixun
dc.date.accessioned2023-09-11T08:39:19Z
dc.date.available2023-09-11T08:39:19Z
dc.date.issued2023
dc.description.abstractMacrophage influences peripheral nerve regeneration. According to the classical M1/M2 paradigm, the M1 macrophage is an inhibitor of regeneration, while the M2 macrophage is a promoter. However, several studies have shown that M1 macrophages are indispensable for peripheral nerve repair and facilitate many critical processes in axonal regeneration. In this review, we summarized the information on macrophage polarization and focused on the activities of M1 macrophages in regeneration. We also provided some examples where the macrophage phenotypes were regulated to help regeneration. We argued that the coordination of both macrophage phenotypes might be effective in peripheral nerve repair, and a more comprehensive view of macrophages might contribute to macrophage-based immunomodulatory therapies.es
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dc.format.extent13es
dc.identifier.citationHistology and Histopathology Vol. 38, nº9 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-591
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/133806
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMacrophagees
dc.subjectMacrophage polarizationes
dc.subjectPeripheral nerve injuryes
dc.subjectPeripheral nerve regenerationes
dc.subjectRegenerative medicinees
dc.subjectImmunomodulatory therapyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe significance of M1 macrophage should be highlighted in peripheral nerve regenerationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº9 (2023)