Publication: Differential expression of laminin isoform (a2), integrins (a3B1 and a6B4) and cytokeratin 20 in H. pylori gastritis
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Date
2001
Authors
Sales, M.G.F. ; Nasciutti, L.E. ; Lorena, D.E. ; Muzzi, M. ; Porto, L.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The expression of laminin-l chains (131 and
yl), laminin-2 (merosin), integrin receptors to laminin
(a3131 and a6134) and cytokeratin (CK20) were studied
by immunohistochemical methods in gastric biopsies
from antrum of 25 patients. H. pylori gastritis was found
in 19 cases and intestinal metaplasia (IM) in four from
these 19. Another 13 biopsies, all with IM were
immunostained to laminin-2. Laminin-l chains in
normal and gastritis areas without 1M were expressed as
a strong, linear and continuous deposit in the basement
membranes of the superficial and glandular epithelium.
In metaplastic glands the reactivity to laminin-l chains
was decreased. Merosin was discontinuous when a
moderate to accentuated H. pylori glandular colonization
was present. Samples with IM were negative to laminin-
2. The a3131 and a6134 integrins were negative only in
IM gastric biopsies. The CK20 immunoreactivity was
strong and homogeneous in the cells at the tip and the
upper portion of foveolae in normal areas and in gastritis
with IM the reactivity to CK 20 was heterogeneous. A
differential expression of laminin isoforms is related to
inflammation and subsequent IM caused by H, pylori.
The alterations of a3131 and a6D4 parallel both
modifications in merosin and CK20 expression in H.
py10r.i chronic gastritis.
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