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Characterisation of the interaction among oil-in-water nanocapsules and mucin

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dc.contributor.authorCollado-González, Mar
dc.contributor.authorKaur, Gurmeet
dc.contributor.authorGonzález-Espinosa, Yadira
dc.contributor.authorBrooks, Rebecca
dc.contributor.authorGoycoolea Valencia, Francisco Martín
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-09-25T07:14:21Z
dc.date.available2025-09-25T07:14:21Z
dc.date.copyright© 2020, by the authors
dc.date.issued2020-07-28
dc.description.abstractMucins are glycoproteins present in all mucosal surfaces and in secretions such as saliva. Mucins are involved in the mucoadhesion of nanodevices carrying bioactive molecules to their target sites in vivo. Oil-in-water nanocapsules (NCs) have been synthesised for carrying N,N0-(di-m-methylphenyl)urea (DMTU), a quorum-sensing inhibitor, to the oral cavity. DMTU-loaded NCs constitute an alternative for the treatment of plaque (bacterial biofilm). In this work, the stability of the NCs after their interaction with mucin is analysed. Mucin type III from Sigma-Aldrich has been used as the mucin model. Mucin and NCs were characterised by the multi-detection symmetrical flow field-flow fractionation technique (AF4). Dynamic light scattering (DLS) and z-potential analyses were carried out to characterise the interaction between mucin and NCs. According to the results, loading DMTU changes the conformation of the NC. It was also found that the synergistic interaction between mucin and NCs was favoured within a specific range of the mucin:NC ratio within the first 24 h. Studies on the release of DMTU in vitro and the microbial activity of such NCs are ongoing in our lab.
dc.formatapplication/pdf
dc.format.extent17
dc.identifier.citationBiomimetics 2020, 5, 36
dc.identifier.doihttps://doi.org/10.3390/biomimetics5030036
dc.identifier.issn2313-7673
dc.identifier.urihttp://hdl.handle.net/10201/161429
dc.languageeng
dc.publisherMDPI
dc.relationM.C.G. acknowledges the fellowship for postdoctoral training (20381/PD/17) funded by the Consejería de Empleo, Universidades y Empresa de la CARM, through the Fundación Séneca de la Región de Murcia. G.K. acknowledges the Newton International Fellowship (NIF\RI\180856) from the Academy of Medical Sciences, United Kingdom.
dc.relation.publisherversionhttps://www.mdpi.com/2313-7673/5/3/36
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMucin
dc.subjectquorum sensing
dc.subjectOil-in-water nanoparticles
dc.subjectChitosan
dc.subjectStability
dc.subjectζ-potential
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleCharacterisation of the interaction among oil-in-water nanocapsules and mucin
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
relation.isAuthorOfPublicationba32f760-d55c-40a7-9452-62dfd47cbeaf
relation.isAuthorOfPublicationb9a16197-ec5b-45bf-a4a5-e0a4499b7d58
relation.isAuthorOfPublication.latestForDiscoveryba32f760-d55c-40a7-9452-62dfd47cbeaf
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