Publication: Goodpasture's syndrome in ageing. An experimental study on the rat. II
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Date
1993
Authors
Escolar Castellón, J.de D. ; Mateos, J. ; Alfaro, E. ; Escolar, M.A. ; Miñana Amada, C. ; Roche, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The following hypothesis is suggested: if a
lung disease is induced in an adult rat, then its lung, in
the senile age, will be different from what is considered
to be a normal senile lung. In order to demonstrate this,
the pulmonary state of two groups of old rats, one of
which had suffered from Goodpasture's syndrome in the
adult age has been assessed morphometrically.
Fifty-three Wistar rats were used. They were divided
into two groups: 1) healthy old rats; and 2) diseased old
rats. Antipulmonary serum was administered to the latter
and they were sacrificed a year later. Making use of a
computing system, we calculated the following data for
each group: the alveolar chord length, the alveolar wall
thickness and the surface of the bronchial-associated
lymphoid tissue (BALT). The alveolar macrophages
(AM) with haemosiderin which were found in the lung
tissue were also counted and the percentage of goblet
bronchial cells and that of bronchoalveolar lavage
(BAL) cells was also assessed.
From the results, the following points should be
emphasized: in diseased old rats, an increase in the
alveolar chord, a decrease in lymphocytes with an
increase in the AM of the BAL, and a decrease in goblet
cells and AM with haemosiderin occur, al1 of which are
significant when these rats are compared to healthy old
rats.
From this experiment it can be inferred that the lungs
of the diseased old rats are morphologically different
from those of the healthy old rats; the findings cannot be
related to an inflammatory process.
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