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Canine C-reactive protein measurements in cerebrospinal fluid by a time-resolved immunofluorimetric assay

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dc.contributor.authorMartínez Subiela, Silvia
dc.contributor.authorCaldin, Marco
dc.contributor.authorParra Muñoz, María Dolores
dc.contributor.authorOttolini, Nicola
dc.contributor.authorBertolini, Giovanna
dc.contributor.authorBernal, Luis J.
dc.contributor.authorGarcía Martínez, Juan Diego
dc.contributor.authorCerón Madrigal, José Joaquín
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2025-01-22T08:03:42Z
dc.date.available2025-01-22T08:03:42Z
dc.date.issued2011-01-01
dc.description© 2011, American Association of Veterinary Laboratory Diagnosticians. This document is the Published version of a Published Work that appeared in final form in Journal of Veterinary Diagnostic Investigation. To access the final edited and published work see https://doi.org/10.1177/104063871102300109es
dc.description.abstractIn the current study, the quantification of C-reactive protein (CRP) in cerebrospinal fluid (CSF) of dogs using an adapted time-resolved immunofluorimetric assay (TR-IFMA) was investigated, as well as whether the assay could be used to detect the range of CRP concentrations found in different clinical situations. Intra- and interassay coefficients of variation were below 15% in all cases. The TR-IFMA measured the CRP values in a proportional and linear manner (r 5 0.99); also CRP concentrations measured in CSF and in serum were significantly correlated (r 5 0.80, P 5 0.003). The limit of detection of the method was 7.1 3 1026 mg/l. The assay was able to detect differences in CRP concentrations in CSF of dogs with inflammatory disorders compared with dogs with spinal cord compression or idiopathic epilepsy. In conclusion, TR-IFMA constitutes a very sensitive, precise, and accurate method for the measurement of CRP concentrations in CSF.es
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dc.format.extent5es
dc.identifier.citationJ Vet Diagn Invest 23:63–67 (2011)
dc.identifier.doihttps://doi.org/10.1177/104063871102300109
dc.identifier.issnPrint: 040-6387
dc.identifier.issnElectronic: 1943-4936
dc.identifier.urihttp://hdl.handle.net/10201/148985
dc.languageenges
dc.publisherSAGE Publicationses
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://journals.sagepub.com/doi/full/10.1177/104063871102300109es
dc.rightsinfo:eu-repo/semantics/embargoedAccesses
dc.subjectCerebrospinal fluides
dc.subjectC-reactive proteines
dc.subjectDogses
dc.subjectTime-resolved immunofluorimetric assayes
dc.titleCanine C-reactive protein measurements in cerebrospinal fluid by a time-resolved immunofluorimetric assayes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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