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Cellular mechanisms of the blood-brain barrier (BBB) opening to albumin-gold complex

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dc.contributor.authorVorbrodt, A.W.es
dc.contributor.authorLossinsky, A.S.es
dc.contributor.authorDobrogowska, D.H.
dc.contributor.authorWisniewski, H.M.
dc.date.accessioned2011-02-01T09:16:09Z
dc.date.available2011-02-01T09:16:09Z
dc.date.issued1993
dc.description.abstractCold lesion injury applied to mouse brain and infusion of hyperosmolar L(+) arabinose solution into rat carotid artery were used as extravascular and intravascular insults, respectively, leading to blood-brain barrier (BBB) disruption. To study the cellular mechanisms of the BBB opening, heterologous (bovine) and homologous (mouse and rat) albumin-gold complexes were used as a macromolecular tracer. Both insults rapidly induce the leakage of the blood-borne tracer, although the mechanisms of their action appear to be different. Cold lesion injury (cryoinjury) leads to the opening of interendothelial junctions and concomitantly to an endothelial-platelet reaction. This insult is followed by irreversible changes such as desquamation, degeneration and necrosis of the endothelial lining, formation of thromboses, and disruption of the basement membrane. Osmotic opening occurs through at least the four mechanisms (presumably temporal and reversible) that follow: 1) opening of a part of the junctional complexes; 2) the formation of transendothelial openings (interendothelial gaps or penetrating, crater-like excavations); 3) the uncontrolled passage of tracer particles through the cytoplasm of the injured endothelial cells; and 4) segmental denudation of the endothelial lining. The basement membrane appears to represent one of the main obstacles in the passage of blood-borne albumin-gold complexes to the extracellular space in the brain parenchyma.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18379
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectBlood brain barrieres
dc.subjectHyperosmolarityes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleCellular mechanisms of the blood-brain barrier (BBB) opening to albumin-gold complexes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 8, nº 1 (1993)