Publication: Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats
Authors
Tanaka, Natsuki ; Izawa, Takeshi ; Takenaka, Shigeo ; Yamate, Jyoji ; Kuwamura, Mitsuru
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-589
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info:eu-repo/semantics/article
Description
Abstract
. Coiled-coil domain containing 85c
(Ccdc85c) is a causative gene for spontaneous mutant
mouse with non-obstructive hydrocephalus and
subcortical heterotopia. Detailed functions of Ccdc85C
protein have not been clarified. To reveal roles of
Ccdc85C, we examined the distribution and expression
pattern of Ccdc85C in the systemic developing organs in
rats. Ccdc85C was expressed in various simple epithelia
but not stratified epithelia. In the various epithelia,
Ccdc85C was localized at cell-cell junctions and its
expression was strong at apical junctions. Furthermore,
intense expression was seen at developing period and
gradually decreased with advancing development.
Distribution of Ccdc85C coincides with that of
proliferating epithelial cells. These results suggest that
Ccdc85C plays an important role in the proliferative
property of simple epithelia.
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Citation
Histology and Histopathology, vol.30, nÂş 7, (2015)
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