Publication: CD1 S-containing glycoconjugates in the central nervous system
Authors
Gocht, A. ; Struckhoff, G. ; Lohler, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
CD15-containing glycoconjugates have a
common trisaccharide residue, 3-fucosyl-N-acetyllactosamine,
which can be recognized by a panel of
monoclonal antibodies. Immunohistochemical studies
revealed a widespread distribution of CD15 in several
epithelial non-neural tissues as well as in the CNS.
In the mature mammalian brain CD15-containing
glycolipids and glycoproteins are constantly present in
astrocytes, whereas oligodendrocytes and particular
subpopulations of neurons are variably immunostained.
CD15 immunoreactive astrocytes are spatially
distributed in some brain regions, which points to
specialized functions of astroglial subpopulations. The
expression of CD15 follows a timely ordered pattern
during the development of glial cells and neurons of
certain brain areas, such as the human and rat cerebellum
and the mouse visual system. During morphogenesis,
CD15 may exert either growth-promoting or growthrepulsive
activities to guide cell migration. In CNS
lesions altered expression patterns of CD15 may occur.
For example, in human gliomas the staining intensity
for CD15 inversely correlates with the grade of
malignancy. In degenerative brain diseases reactive
astrocytes may reveal an increased labelling intensity on
their cell surface as well as an abnormal cytosolic
accumulation of the epitope. The functional significance
of CD15 in the CNS is not exactly known yet. The
carbohydrate could be involved in cellular adhesion
andtor as receptor molecule in signal transduction
pathways, as has recently been demonstrated for
leukocyte-platelet or leukocyte-endothelial cell
interactions.
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