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The aging rat retina: from function to anatomy

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dc.contributor.authorNadal-Nicolás, Francisco Manuel
dc.contributor.authorVidal Sanz, Manuel
dc.contributor.authorAgudo Barriuso, Marta
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2026-01-27T20:02:23Z
dc.date.available2026-01-27T20:02:23Z
dc.date.copyright© 2017 The Author(s)
dc.date.issued2018-01-01
dc.description.abstractIn healthy beings, age is the ultimate reason of cellular malfunction and death. In the rat retina, age causes a functional decline and loss of specific neuronal populations. In this regard, controversial conclusions have been reported for the innermost retina. Here, we have studied the albino and pigmented retina for the duration of the rat life-span. Independent of age (21 dayse22 months), the electroretinographic recordings and the volume of the retina and its layers are smaller in albinos. Functionally, aging causes in both strains a loss of cone- and rod-mediated responses. Anatomically, cell density decreases with age because the retina grows linearly with time; no cell loss is observed in the ganglion cell layer; and only in the pigmented rat, there is a decrease in cone photoreceptors. In old animals of both strains, there is gliosis in the superior colliculi and a diminution of the area innervated by retinal ganglion cells. In conclusion, this work provides the basis for further studies linking senescence to neurodegenerative retinal diseases.
dc.formatapplication/pdf
dc.format.extent22
dc.identifier.citationNeurobiol Aging. 2018 Jan;61:146-168
dc.identifier.doihttps://doi.org/10.1016/j.neurobiolaging.2017.09.021
dc.identifier.eissn1558-1497
dc.identifier.issn0197-4580
dc.identifier.urihttp://hdl.handle.net/10201/195529
dc.languageeng
dc.publisherElsevier
dc.relationFundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (19881/GERM/15), and the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional “Una Manera de Hacer Europa” (SAF2015-67643-P, PI16/00031, RD12/0034/0014)
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0197458017303172
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnterograde axonal transport
dc.subjectBrn3a
dc.subjectCone
dc.subjectMelanopsin
dc.subjectMicroglia
dc.subjectOptical coherence tomography
dc.subjectRods
dc.subjectPhotoreceptors
dc.subject.odsObjetivo 3: Salud
dc.titleThe aging rat retina: from function to anatomy
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublication.latestForDiscoveryba9bf053-48ec-4e39-93ac-ffcbaf10fc0f
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