Publication: Tumor-associated fibroblasts (Part I): active stromal participants in tumor development and progression?
Authors
Kunz-Schughart, L.A. ; Knuechel, R.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Phenotypic and functional characteristics of
tumor associated fibroblasts (TAF) in contrast to normal
fibroblasts are re
v i e
wed in this first synopsis (part I).
Terms
as
tumor
stroma,
desmo-plasia,
T
A F
,
myofibroblast, and fetal-type fibroblast are defined, and
experimental systems to study heterologous cell
interactions are presented.
While we only start to gather information on the
genotype of T
A F
, a broad range of data deals with the
e
xpression profile of these cells, co
v
ering e.g. ECM and
ECM-modulating molecules, growth factors and
cytokines. Summarizing the recent state of kno
w l e d g e
indicates that TAF provide sources for tumor diagnosis
and therap
y
, that ha
v
e to be further defined in an or
g
an-
s p e c i f
ic approach in terms of the functional impact on
the tumor cell and its environment (see part II).
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Citation
Histology and histopathology, Vol. 17, nº 2 (2002)
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