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Intraosseous squamous cell carcinoma associated with denosumab-induced osteonecrosis of the jaw

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dc.contributor.authorBacián Martínez, Sandra
dc.contributor.authorNavarro Cuéllar, Carlos
dc.contributor.authorNavarro Vila, Carlos
dc.contributor.authorPalacios Weiss, Edurne
dc.contributor.authorPujol Romanyá, Roser
dc.contributor.authorAmo Fernández de Velasco, Álvaro del
dc.contributor.authorEscrig de Teijeiro, Margarita
dc.contributor.authorCastillo Pardo de Vera, josé Luis del
dc.contributor.authorRodríguez Pérez, Irene
dc.contributor.authorSánchez Pérez, Arturo Joaquín
dc.contributor.authorZamorano-León, José J.
dc.contributor.authorLópez-Farré, Antonio
dc.contributor.authorGarcía-Hidalgo Alonso, María Isabel
dc.contributor.authorNavarro Cuéllar, Ignacio
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2026-01-29T11:25:52Z
dc.date.available2026-01-29T11:25:52Z
dc.date.copyright© 2021 by the authors
dc.date.issued2021-08-20
dc.description.abstractMedication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activation of the RANK receptor on the surface of osteoclasts, has been associated with osteonecrosis of the jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterised by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa. We present a case of a PIOSCC in an osteonecrosis of the jaw related to a patient who received antiresorptive treatment with denosumab outlining the clinical and histopathological features of MRONJ and PIOSCC.
dc.formatapplication/pdf
dc.format.extent7
dc.identifier.citationAppl. Sci. 2021, 11, 7646
dc.identifier.doihttps://doi.org/10.3390/app11167646
dc.identifier.eissn2076-3417
dc.identifier.urihttp://hdl.handle.net/10201/196789
dc.languageeng
dc.publisherMDPI
dc.relationSin financiación externa a la Universidad
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/11/16/7646
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDenosumab
dc.subjectMedication related osteonecrosis of the jaw (MRNOJ)
dc.subjectPrimary intraosseous squamous cell carcinoma
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleIntraosseous squamous cell carcinoma associated with denosumab-induced osteonecrosis of the jaw
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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relation.isAuthorOfPublication7ba0b8fd-9530-45d9-aed3-569152fd12de
relation.isAuthorOfPublication.latestForDiscovery7ba0b8fd-9530-45d9-aed3-569152fd12de
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