Publication: The immunohistochemical expression of metallothionein in inflammatory bowel disease. Correlation with HLA-DR
antigen expression, lymphocyte subpopulations and
proliferation-associated indices
Authors
Loachim, E. ; Michael, M. ; Katsanos, C. ; Demou, A. ; Tsianos, E.V.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Metallothionein (MT) expression in
intestinal resection specimens from 41 patients with
ulcerative colitis (UC) and 10 patients with Crohn’s
disease (CD ) was immunohistochemically studied by
the avidin-biotin (ABC) method. In addition, the
possible relationship of its expression with HLA-DR
antigen expression, lymphocyte subpopulations and
proliferation-associated indices was studied in order to
elucidate the role of this molecule in inflammatory
bowel disease (IBD). The MT immunoreactivity was
recorded by staining and intensity-distribution scores.
MT staining varied in and was mainly localized in the
cytoplasm, although a combined nuclear/cytoplasmic
reactive pattern was also seen in epithelial cells. MT
expression was decreased in UC, and CD compared with
normal mucosa. No difference in MT expression
between UC and CD was noted. In UC, a gradually
decreased expression from remission, to resolving and to
active phase was observed. An inverse correlation of MT
expression with HLA-DR antigen expression was
detected (p=0.018) in the cases of UC. The data suggest
that a low level of MT expression in inflammatory
bowel disease and particularly in active phase of UC
may indicate a decreased endogenous intestinal
protection and it may be implicated in the pathogenesis
of the disease.
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