Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet

Suárez Martínez, Clara; Santaella-Pascual, Marina; Yagüe Guirao, Genoveva; Martínez Gracia, Carmen

Publication:
Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet

dc.contributor.author	Suárez Martínez, Clara
dc.contributor.author	Santaella-Pascual, Marina
dc.contributor.author	Yagüe Guirao, Genoveva
dc.contributor.author	Martínez Gracia, Carmen
dc.contributor.department	Tecnología de Alimentos, Nutrición y Bromatología
dc.contributor.other	Facultad de Veterinaria
dc.date.accessioned	2026-01-22T18:57:15Z
dc.date.available	2026-01-22T18:57:15Z
dc.date.copyright	© 2023 Suárez-Martínez, Santaella-Pascual, Yagüe-Guirao and Martínez-Graciá
dc.date.issued	2023-08-22
dc.description.abstract	Maternal microbiota forms the first infant gut microbial inoculum, and perinatal factors (diet and use of antibiotics during pregnancy) and/or neonatal factors, like intra partum antibiotics, gestational age and mode of delivery, may influence microbial colonization. After birth, when the principal colonization occurs, the microbial diversity increases and converges toward a stable adult-like microbiota by the end of the first 3–5 years of life. However, during the early life, gut microbiota can be disrupted by other postnatal factors like mode of infant feeding, antibiotic usage, and various environmental factors generating a state of dysbiosis. Gut dysbiosis have been reported to increase the risk of necrotizing enterocolitis and some chronic diseases later in life, such as obesity, diabetes, cancer, allergies, and asthma. Therefore, understanding the impact of a correct maternal-to-infant microbial transfer and a good infant early colonization and maturation throughout life would reduce the risk of disease in early and late life. This paper reviews the published evidence on early-life gut microbiota development, as well as the different factors influencing its evolution before, at, and after birth, focusing on diet and nutrition during pregnancy and in the first months of life.
dc.format	application/pdf
dc.format.extent	26
dc.identifier.citation	Front. Microbiol. 14:1236254
dc.identifier.doi	https://doi.org/10.3389/fmicb.2023.1236254
dc.identifier.eissn	1664-302X
dc.identifier.uri	http://hdl.handle.net/10201/191229
dc.language	eng
dc.publisher	Frontiers Media
dc.relation	This research was supported by the Spanish Ministry of Science, Innovation and Universities (grant number PID2019-106693RB-100/AEI/10.13039/501100011033).
dc.relation.publisherversion	https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1236254/full
dc.rights	Attribution 4.0 International	*
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Gut microbiota
dc.subject	Breast-feeding
dc.subject	Diet
dc.subject	Delivery mode
dc.subject	Colonization
dc.subject	Pregnancy
dc.subject	Newborn
dc.subject	Infant
dc.subject.ods	Objetivo 3: Salud
dc.title	Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
dc.type	info:eu-repo/semantics/article
dc.type.version	info:eu-repo/semantics/publishedVersion
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