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Altered materno-fetal transfer of 13C-polyunsaturated fatty acids in obese pregnant women.

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dc.contributor.authorGázquez, A.
dc.contributor.authorPrieto-Sánchez, Maria T.
dc.contributor.authorBlanco-Carnero, J.E.
dc.contributor.authorRuiz-Palacios, M.
dc.contributor.authorNieto, A.
dc.contributor.authorvan Harskamp, D.
dc.contributor.authorOosterink, J.E.
dc.contributor.authorSchierbeek, H.
dc.contributor.authorvan Goudoever, J.B.
dc.contributor.authorDemmelmair, H.
dc.contributor.authorKoletzko, B.
dc.contributor.authorLarqué, E.
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.date.accessioned2024-02-11T17:35:41Z
dc.date.available2024-02-11T17:35:41Z
dc.date.issued2020-04
dc.description©2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted, version of a Published Work that appeared in final form in Clinical Nutrition. To access the final edited and published work see https://doi.org/10.1016/j.clnu.2019.04.014es
dc.description.abstractMaternal obesity at conception is considered a major predictor of offspring obesity. This could by driven at least in part by an altered placental fat transfer. However, the pathophysiological mechanisms involved are not fully understood. We investigated the in vivo materno-fetal transfer of fatty acids (FAs) in obese pregnant women using stable isotopes. Ten obese and ten normo-weight pregnant women (control) received orally a bolus of 13C-labeled FAs 12 h before elective caesarean section: oleic acid (13C-OA), linoleic acid (13C-LA) and docosahexaenoic acid (13C-DHA). Maternal blood samples were collected at -12 (basal), -8, -4, -2, 0 h relative to the time of cesarean section. At the time of birth, arterial and venous cord bloods as well as placental tissue were collected. FAs composition was determined by gas-liquid chromatography and isotopic enrichment by gas chromatography-combustion-isotope ratio mass spectrometry. Maternal plasma insulin and placental weight tended to higher values in obese pregnant women although they did not present serum hyperlipidemia. Higher concentrations of 13C-LA and 13C-DHA were found in non-esterified FAs fraction in maternal plasma of obese mothers. The ratio of placental uptake for 13C-LA and 13C-DHA was lower in obese women compared to normal weight pointing toward a limited capacity of FA placental transfer, especially of essential FAs. Maternal insulin was associated to this lower placenta/maternal plasma ratio for both 13C-LA (R = -0.563, P = 0.012) and 13C-DHA (R = -0.478, P = 0.033). In addition, the ratio cord/maternal plasma of 13C-LA was significantly lower in obese women compared to controls. In conclusion, obese mothers without hyperlipidemia showed a reduced materno-fetal transfer of polyunsaturated FAs which could affect fetal development. This affect dietary recommendation for obese pregnant women.es
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dc.format.extent35es
dc.identifier.citationClinical Nutrition. 2020 Apr 39(4):1101-1107
dc.identifier.doihttps://doi.org/10.1016/j.clnu.2019.04.014
dc.identifier.issn0261-5614
dc.identifier.urihttp://hdl.handle.net/10201/139244
dc.languageenges
dc.relationThis work is financially supported in part by the Commission of theEuropean Communities,Projects Early Nutrition (FP7-289346), DYNAHEALTH(H2020-633595) and LIFECYCLE (H2020-SC1-2016RTD), the European Research Council Advanced Grant METAGROWTH (ERC-2012-AdG322605), and the Excellence Networkfor Maternaland Child Health and Development (REDSAMIDIII,RD16/ 0022/0009).es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleAltered materno-fetal transfer of 13C-polyunsaturated fatty acids in obese pregnant women.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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