Publication: Localization of insulin-like immunoreactive neurons in the rat gracile nucleus
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Date
1996
Authors
Dheen, S.T. ; Tay, S.S.W. ; Wong, W. C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
An insulin-like immunoreactivity (ILIR) was
localized in the neuronal somata, dendrites and
myelinated axons in the gracile nucleus of the male
Wistar rat. In the neuronal somata, the reaction product
was dispersed in the cell nucleus and cytoplasm. In the
cell nucleus, the reaction product was scattered
throughout the nucleoplasm, but not within the
nucleolus. In the cytoplasm, the reaction product was
evenly distributed, mainly in the vicinity of the cistemae
of the rough endoplasmic reticulum. In labelled
dendrites, the reaction product was closely associated
with the parallel arrays of neurotubules and postsynaptic
densities. Most of these labelled dendrites were
postsynaptic to unlabelled axon terminals. A labelled
dendrite often formed the central element of a synaptic
glomerulus with several unlabelled axon terminals.
Numerous labelled myelinated axons were also present
in the neuropil. However, axon terminals appeared to be
unlabelled. It is hypothesized that insulin-like
substance(s) may be modulating nuclear activities as
well as neurotransmission at the synapse in the gracile
nucleus.
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