Publication: Adhesion-dependent signalling and the initiation of haemostasis and thrombosis
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Date
1998
Authors
Andrews, R.K. ; Berndt, M.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cell-cell and cell-extracellular matrix
adhesion are critical aspects of platelet function,
regulating interactions between circulating platelets in
the bloodstream with the blood vessel wall. In
haemostasis, platelets adhere to the subendothelial
matrix of a damaged vessel, spread over the surface and
recruit additional platelets within a developing platelet
aggregate or thrombus. In addition to this normal
physiological response, platelet adhesion is critical in
the pathological process of thrombosis, where
circulating platelets adhere to sclerotic lesions or
undergo shear-induced aggregation within vessels
occluded by atherosclerotic plaque. Under these
circumstances, the resulting thrombus may result in
acute myocardial infarction or stroke. Each stage of
platelet adhesion and aggregation in haemostasis and
thrombosis is regulated by specific cell surface adhesion
receptors. Interestingly, most of the adhesive receptors
studied in detail have been found not only to regulate
contact adhesion, but also to transduce intracellular
signals that activate the cell, initiate post-adhesion
cellular events, and regulate the adhesive function of
other receptors. Platelet activation triggers the
cytoskeletal rearrangements that control cell shape
change, spreading, secretion, aggregation and
contraction. This review will focus on adhesiondependent
signalling induced by the platelet surface receptor, the glycoprotein (GP) Ib-IX-V complex, that
initiates thrombus formation in both haemostasis and
thrombosis under conditions of high shear blood flow.
Emerging evidence suggests GP Ib-IX-V-dependent
signalling may involve receptor cross-linking and the
cytoplasmic signalling protein, 14-3-3 f.
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