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Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats

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dc.contributor.authorCarmona-Calero, E.es
dc.contributor.authorPérez-González, H.es
dc.contributor.authorMartínez de la Peña y Valenzuela, Isabel
dc.contributor.authorGonzalez-Marrero, I.
dc.contributor.authorPerez-Garcia, C.G.
dc.contributor.authorMarrero-Gordillo, N.
dc.contributor.authorOrmazabal-Ramos, C.
dc.contributor.authorCastañeyra Perdomo, A.
dc.contributor.authorFerres Torres, R.
dc.date.accessioned2011-06-30T11:59:52Z
dc.date.available2011-06-30T11:59:52Z
dc.date.issued2005
dc.description.abstractWe studied the effects of spontaneous high blood pressure and the captopril treatment on the subfornical organ (SFO) of rats. The brains of control Wistar-Kyoto rats (WKY), WKY rats treated with captopril (WKY-T), spontaneously hypertensive rats (SHR) and SHR rats treated with captopril (SHR-T) were processed immunohistochemically using antiangiotensin II as primary antibody. Immunorective material (IRM) for angiotensin II was observed in a group of neurons and some cells of the ependymal layer of the SFO in WKY rats. The angiotensin II immunoreactive (AGII-ir) in the SHR rats was decreased, showing positive reaction only in a few neurons, while captopril treatment induced an increase in immunoreactive material in hypertensive rats, but contrarily, the expression of AGII-ir in the WKY-T group was scarce. The variations of the angiotensin II observed in the SFO could be owing to an interaction between the hypertension and its captopril treatment.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22446
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHypertensiones
dc.subjectCaptopriles
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleEffect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR ratses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.20, nº 1 (2005)