Publication: Fascin in ovarian epithelial tumors
Authors
Kostopoulou, Evanthia ; Daponte, Alexandros ; Terzis, Anastasios ; Nakou, María ; Chiotoglou, Ioanna ; Theodosiou, Dimitrios ; Chatzichristodoulou, Christos ; Messinis, Ioannis E. ; Koukoulis, George
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Fascin contributes to the formation of actinbased
protrusions involved in cell migration. Fascin has
emerged as a prognostic marker in some carcinomas. We
examined ovarian neoplasms to check any correlation
between fascin expression and established
clinicopathologic parameters.
Fascin immunoreactivity was semiquantitavely
scored in 100 ovarian tumors (62 carcinomas, 15
borderline tumors and 23 cystadenomas). Double
staining for fascin and Ki-67 was performed in selected
carcinomas. Western Blotting was done in frozen
samples.
Fascin immunoreactivity was highest in carcinomas,
lowest in cystadenomas and intermediate in borderline
tumors; these results were in accordance with those from
Western blotting analysis. Fascin was statistically
increased in carcinomas of advanced stage and in serous
carcinomas. It was also increased in metastatic foci and
in tumor foci with lower Ki-67 labeling.
We conclude that in ovarian tumors fascin is
associated with certain features of increased tumor
aggressiveness. Future studies could determine if fascin
may become a routinely helpful marker in gynecological
pathology or clinical oncology.
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