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Donor-derived cell-free DNA in allograft transplantation: exaggerated hope or cautious reality?

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dc.contributor.authorFernández-González, Marina
dc.contributor.authorLlorente, Santiago
dc.contributor.authorBotella, Carmen
dc.contributor.authorGalián, José Antonio
dc.contributor.authorGonzález-López, Rosana
dc.contributor.authorAlegría-Marcos, María José
dc.contributor.authorHita, Alicia
dc.contributor.authorMoya-Quiles, Rosa
dc.contributor.authorMartínez-Banaclocha, Helios
dc.contributor.authorMuro-Pérez, Manuel
dc.contributor.authorMuro, Javier
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.authorMuro, Manuel
dc.contributor.departmentCiencias Sociosanitarias
dc.contributor.otherFacultad de Química
dc.date.accessioned2026-01-22T09:56:54Z
dc.date.available2026-01-22T09:56:54Z
dc.date.copyright© 2025 by the authors
dc.date.issued2025-09-23
dc.description.abstractNowadays, there have truly been spectacular advances in surgical techniques, the preservation of organs for transplants, the optimal and efficient selection of both donors and recipients, a more efficient diagnosis and prediction of possible complications of transplants, and important progress in the advances of pharmacological immunosuppression protocols and procedures. In this sense, survival rates after transplantation of various organs have been progressively increasing, especially in the case of lung transplants, whose average survival rate is usually lower than that of other types of solid organ transplants. Thus, detecting acute and subclinical rejection and chronic allograft rejection of any implant is important. This is important in all transplants, such as heart and lung transplants. In this last type of transplant, particularly, and due to the chronic dysfunction of the lung allograft, it is key to detect rejection early and on time, since it can reach close to half of the transplant patient population. Therefore, practical diagnostic tools are needed to visualize the level of allograft damage using genomic methods such as those that measure donor-derived cell-free DNA, where its amount increases in the plasma component of the transplant after tissue injury or due to allograft infection. This biomarker has become a key element with light and hope, but with some shadows of caution due to its use as a panacea. Our research team has experience in solid organ transplantation in quantifying this parameter in the progression of the lesion of the implanted allograft, and our experience and comparison with the published literature will be presented in the following review, discussing validated and non-validated results.
dc.formatapplication/pdf
dc.format.extent17
dc.identifier.citationBiomedicines 2025, 13, 2325
dc.identifier.eissn2227-9059 |
dc.identifier.urihttp://hdl.handle.net/10201/190549
dc.languageeng
dc.publisherMDPI
dc.relationThis research was funded by Instituto de Salud Carlos III (ISCIII), the Spanish Ministry of Economics, and Competitiveness. Grant Number PI19/01194 co-funding of the EU with the European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe” and project of “Fundacion Mutua Madrileña” Grant Number AP183152023.
dc.relation.publisherversionhttps://www.mdpi.com/2227-9059/13/10/2325
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAllograft rejection
dc.subjectBiomarker
dc.subjectChronic kidney disease
dc.subjectDonorderived cell-free DNA
dc.subjectTolerance
dc.subjectAcute rejection
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleDonor-derived cell-free DNA in allograft transplantation: exaggerated hope or cautious reality?
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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