Publication: Elimination of transformed cells by normal cells: a novel concept for the control of carcinogenesis
Loading...
Date
1996
Authors
Bauer, G.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Control of transformed cells by neighbouring
normal cells is known since the beginning of
transformation studies in vitro. The classical explanation
for this phenomenon is based on proliferation inhibition
of transformed cells by normal cells. We extend this
model by presenting data that show that TGF-B-treated
normal cells can eliminate transformed cells by
induction of apoptosis. Both the TGF-8-induced signal
pathway in normal cells, leading to the production of a
short-lived apoptosis-inducing factor, as well as the
specific interaction of this factor with transformed cells
depend on the action of reactive oxygen species.
Sensitivity to induction of apoptosis seems to be a
common feature associated with the transformed state,
independent of the originally transforming principle.
Therefore, tumor development should require either
interference with the process of elimination or
acquisition of resistance against it. We discuss
experimental evidence for interfering substances, such as
antioxidants, as well as for genetic systems that protect
transformed cells from the negative effects of their
cellular environment, such as Bcl-2 or papilloma viruses.
These findings, as well as the general resistance of exvivo
tumor cells against induction of apoptosis are in
line with the novel model of control of tumor
progression presented by us in this review.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.