Publication:
The Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methods.

Simple item page
dc.contributor.authorMorales Bartolomé, Eva
dc.contributor.authorCabezas Herrera, Juan
dc.contributor.authorJiménez Guerrero, Pedro
dc.contributor.authorLarque Daza, Elvira
dc.contributor.authorMartinez Gracia, María del Carmen
dc.contributor.authorMartinez Torres, Antonela
dc.contributor.authorMendiola Olivares, Jaime
dc.contributor.authorNieto Diaz, Anibal
dc.contributor.authorPérez Fernández, Virginia
dc.contributor.authorPrieto Sánchez, María Teresa
dc.contributor.authorSalvador García, Carme
dc.contributor.authorSánchez Solís De Querol, Manuel
dc.contributor.authorTorres Cantero, Alberto M.
dc.contributor.authorYagüe Guirao, Genoveva
dc.contributor.authorZornoza Moreno, Matilde
dc.contributor.authorGarcía Marcos Álvarez, Luis V.
dc.contributor.authorLópez Soler, Concepción
dc.contributor.authorSantaella-Pascual, Marina
dc.contributor.authorDiego Puente, Teresa de
dc.contributor.authorHernández Caselles, Trinidad
dc.contributor.authorMartín-Orozco Santiago, María Elena
dc.contributor.authorSola Martínez, Rosa Alba
dc.contributor.authorNoguera Velasco, José Antonio
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2023-12-12T23:11:54Z
dc.date.available2023-12-12T23:11:54Z
dc.date.issued2021-09-19
dc.descriptionThis document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the accepted version of a Published Work that appeared in final form in Paediatric and Perinatal Epidemiology. To access the final edited and published work see https://doi.org/10.1111/ppe.12826
dc.description.abstractBackground: Primary prevention strategies for asthma are lacking. Its inception probably starts in utero and/or during the early postnatal period as the developmental origins of health and disease (DOHaD) paradigm suggests. Objectives: The main objective of Nutrition in Early Life and Asthma (NELA) cohort study is to unravel whether the following factors contribute causally to the developmental origins of asthma: (1) maternal obesity/adiposity and foetal growth; (2) maternal and child nutrition; (3) outdoor air pollution; (4) endocrine disruptors; and (5) maternal psychological stress. Maternal and offspring biological samples are used to assess changes in offspring microbiome, immune system, epigenome and volatilome as potential mechanisms influencing disease susceptibility. Population: Randomly selected pregnant women from three health areas of Murcia, a south-eastern Mediterranean region of Spain, who fulfilled the inclusion criteria were invited to participate at the time of the follow-up visit for routine foetal anatomy scan at 19–22 weeks of gestation, at the Maternal-Fetal Medicine Unit of the “Virgen de la Arrixaca” University Clinical Hospital over a 36-month period, from March 2015 to April 2018. Design: Prospective, population-based, maternal-child, birth cohort study. Methods: Questionnaires on exposures and outcome variables were administered to mothers at 20–24 gestation week; 32–36 gestation week; and delivery. Children were surveyed at birth, 3 and 18 months of age and currently at 5 years. Furthermore, physical examinations were performed; and different measurements and biological samples were obtained at these time points. Preliminary results: Among the 1350 women invited to participate, 738 (54%) were finally enrolled in the study and 720 of their children were eligible at birth. The adherence was high with 612 children (83%) attending the 3 months’ visit and 532 children (72%) attending the 18 months’ visit. Conclusion: The NELA cohort will add original and unique knowledge to the developmental origins of asthma.
dc.formatapplication/pdfes_ES
dc.format.extent15
dc.identifier.citationPaediatric and Perinatal Epidemiology (2022) vol 36 pp. 310--324
dc.identifier.doihttps://doi.org/10.1111/ppe.12826
dc.identifier.issn1365-3016
dc.identifier.urihttp://hdl.handle.net/10201/136575
dc.languageenges_ES
dc.publisherWiley
dc.relationInstituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities (Grants: MS14/00046; CP14/00046; PIE15/00051; PI16/00422; FI17/00086; PI19/00863; FPU18/00545), Fondos FEDER, Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (Grant: 20877/PI/18).
dc.relation.isreferencedbyED_IDENTRADA=1266
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAllergy
dc.subjectAsthma
dc.subjectDiet
dc.subjectMother-child cohort
dc.subjectWheezing
dc.titleThe Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methods.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dspace.entity.typePublicationes
relation.isAuthorOfPublication2d5dac0f-c6c6-485b-97bf-c679f4940e3d
relation.isAuthorOfPublicationb8be181a-7224-475a-8427-543751ef593c
relation.isAuthorOfPublicationc0416b92-3bd1-4c0a-bd7c-df5ae58f3f63
relation.isAuthorOfPublication24de46e8-df34-4c71-a701-2a30b079b958
relation.isAuthorOfPublicatione8f94992-2fb5-4cef-8d69-f99f31938719
relation.isAuthorOfPublicationf3810358-f28e-4db9-88fb-457b1c3f4a1f
relation.isAuthorOfPublication.latestForDiscovery2d5dac0f-c6c6-485b-97bf-c679f4940e3d
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
A48-Paedia..1.pdf
Size:
745.3 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Plain Text
Description:
Written by org.dspace.content.LicenseUtils
Download
Collections
Artículos