Publication: The effects of dexpanthenol in
streptozotocin-induced diabetic rats: Histological,
histochemical and immunological evidences
Authors
Gulle, K. ; Ceri, N.G. ; Akpolat, M. ; Arasli, M. ; Demirci, B.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This study was designed to investigate the
effects of Dexpanthenol (Dxp) on liver and pancreas
histology and cytokine levels in streptozotocine (STZ)-
induced diabetic rats. Twenty-four Wistar albino male
rats were divided into four groups: control, Dxp, STZinduced diabetic (STZ) and diabetic treatment with
Dexpanthenol (STZ-Dxp) groups. Experimental diabetes
was induced by single dose STZ (50 mg/kg)
intraperitoneally (i.p.). After administration of STZ, the
STZ-Dxp group began to receive a 300 mg/kg/day i.p.
dose of Dxp for 6 weeks. Liver and pancreas tissues of
the control group were in normal morphology. Liver
tissue of STZ group showed vacuolisation of
hepatocytes in the liver parenchyma with enlargement of
sinusoidal spaces and increasing amounts of connective
tissue in the portal area. Pancreatic section of STZ group
displayed β-cells with of cytoplasmic mass, reduction of
islet size, and atrophy. The STZ-Dxp group that received
Dxp treatment exhibit partially normal hepatic
parenchyma. Histochemical examinations revealed that
the diabetes-induced glycogen depletion markedly
improved with the Dxp treatment (p<0.001). The
severity of degenerative alteration was lessened by Dxp
supplementation in the STZ-Dxp group. Induction of
STZ presented a significant increase both in interleukin1α (IL-1α) (p=0.033) and monocyte chemotactic
protein-1 (MCP-1) (p=0.011) levels, when compared
with the control rats. DXP-treated diabetic rats’ IL-1α
and MCP-1 levels were similar to control value. This
evidence suggests that Dxp is effective in reducing STZinduced, diabetic-related complications and may be
beneficial for the treatment of diabetic patients.
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Citation
Histology and Histopathology, vol. 29, nº 10, (2014)
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