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Sustainable set-ups for the biocatalytic production and scale-up of panthenyl monoacyl esters under solvent-free conditions

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dc.contributor.authorNieto Cerón, Susana
dc.contributor.authorBernal Palazón, Juana María
dc.contributor.authorGarcía Verdugo, Eduardo
dc.contributor.authorDonaire González, Antonio
dc.contributor.authorLozano Rodríguez, Pedro
dc.contributor.authorVilla Aroca, Rocío
dc.contributor.departmentQuímica Inorgánica
dc.contributor.otherFacultades de la UMU::Facultad de Química
dc.date.accessioned2026-01-19T09:07:57Z
dc.date.available2026-01-19T09:07:57Z
dc.date.copyright© 2023 The Authors.
dc.date.issued2023-03-22
dc.description.abstractA sustainable scaling-up process for the biocatalytic production of new bioactive provitamin-B5 monoacyl esters has been demonstrated. A solvent-free reaction protocol based on the formation of eutectic mixtures between neat substrates render to highly efficient direct esterification of free fatty acids (i.e. from C6 to C18 alkyl chain length) with panthenol catalyzed by lipase. The scale-up from 0.5 to 500 g was evaluated by means of several reaction systems (i.e. ultrasound-assistance, orbital shaking, rotary evaporator, and mechanical stirring coupled to vacuum). For all reactor systems, the yield in panthenyl monoacyl esters was improved by increasing the length of the alkyl chain of the fatty acid (i.e. from 63 % yield for panthenyl butyrate to 83 % yield for panthenyl myristate). The best results (87 % - 95 % product yield, for all cases) were obtained upon a scale-up (50-500 g size) and when a vacuum system was coupled to the biocatalytic reaction unit. Under the optimized conditions a five-fold reduction of the amount of biocatalyst with respect reactors without vacuum was achieved. The recovery and reuse of the immobilized enzyme for 5 operation cycles was also demonstrated. Finally, different metrics have been applied to assess the greenness of the solvent-free biocatalytic synthesis of panthenyl monoesters here reported.
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dc.format.extent34
dc.identifier.citationACS Sustainable Chem. Eng. 2023, 11, 14, 5737–5747
dc.identifier.doihttps://doi.org/10.1021/acssuschemeng.3c00266
dc.identifier.eissn2168-0485
dc.identifier.urihttp://hdl.handle.net/10201/188149
dc.languageeng
dc.publisherAmerican Chemical Society
dc.relationThis work was partially supported by 21640/PDC/21 and 21884/PI/22 (Fundación SENECA-CARM, Spain) and by PID2021-124695OB-C21/C22 and PDC2022-133313-C21/ C22 (MICINN/FEDER/AEI 10.13039/501100011033 and European Union Next Generation EU-PRTR, Spain) grants.
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acssuschemeng.3c00266
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiocatalysis
dc.subjectPanthenol esters
dc.subjectSolvent free
dc.subjectScaling up
dc.subjectSustainable processes
dc.subject.odsObjetivo 7: Energía
dc.titleSustainable set-ups for the biocatalytic production and scale-up of panthenyl monoacyl esters under solvent-free conditions
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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