Publication:
Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project.

Simple item page
dc.contributor.authorCamelo-Castillo, Amy
dc.contributor.authorRivera Caravaca, José Miguel
dc.contributor.authorMarin, Francisco
dc.contributor.authorVicente, Vicente
dc.contributor.authorLip, Gregory Y
dc.contributor.authorRoldán, Vanessa
dc.contributor.departmentMedicina
dc.date.accessioned2024-02-08T09:08:58Z
dc.date.available2024-02-08T09:08:58Z
dc.date.issued2020
dc.description.abstractBackground: The ABC (age, biomarkers, and clinical history)-stroke and ABC-bleeding are biomarker-based scores proposed to predict stroke and bleeding, but non-specificity of biomarkers is common, predicting different clinical events at the same time. We assessed the predictive performance of the ABC-stroke and ABC-bleeding scores, for outcomes beyond ischemic stroke and major bleeding, in a cohort of atrial fibrillation (AF) patients. Methods: We included AF patients stable on vitamin K antagonists for 6 months. The ABC-stroke and ABC-bleeding were calculated and the predictive values for myocardial infarction (MI), acute heart failure (HF), a composite of cardiovascular events, and all-cause deaths were compared. Results: We included 1,044 patients (49.2% male; median age 76 [71-81] years). During 6.5 (4.3-7.9) years, there were 58 (5.6%) MIs, 98 (9.4%) acute HFs, 167 (16%) cardiovascular events, and 418 (40%) all-cause deaths. There were no differences in mean ABC-stroke and ABC-bleeding scores in patients with/without MI (p = 0.367 and p = 0.286, respectively); both scores were higher in patients with acute HF, cardiovascular events, or death (all p < 0.05). Predictive performances for the ABC-stroke and ABC-bleeding scores were similar, ranging from "poor" for MI (c-indexes ∼0.54), "moderate" for acute HF and cardiovascular events (c-indexes ∼0.60 and ∼0.64, respectively), and "good" for all-cause mortality (c-indexes > 0.70). Clinical usefulness whether assessed by ABC-stroke or ABC-bleeding was similar for various primary endpoints. Conclusion: In AF patients, the ABC-stroke and ABC-bleeding scores demonstrated similar predictive ability for outcomes beyond stroke and bleeding, including MI, acute HF, a composite of cardiovascular events, and all-cause deaths. This is consistent with nonspecificity of biomarkers that predict "sick" patients or poor prognosis overall.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationThrombosis and Haemostasis
dc.identifier.doihttps://doi.org/10.1055/s-0040-1712914
dc.identifier.issn0340-6245
dc.identifier.urihttp://hdl.handle.net/10201/138957
dc.languageenges
dc.relationInstituto de Salud Carlos III (PI17/01375 cofinanciado con fondos FEDER (European Regional Development Fund) y el grupo CB16/11/00385 de CIBERCV.es
dc.rightsinfo:eu-repo/semantics/embargoedAccesses
dc.subjectFibrilacion auriculares
dc.subjectBiomarcadores
dc.subjectIctuses
dc.subjectHemorragiaes
dc.titlePredicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
TH 2020.pdf
Size:
270.63 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos