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Blue Copper Proteins: A rigid machine for efficient electron transfer, a flexible device for metal uptake

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dc.contributor.authorPérez-Henarejos, Sergio Alejo
dc.contributor.authorAlcaraz, Luis Antonio
dc.contributor.authorDonaire González, Antonio
dc.contributor.departmentQuímica Inorgánica
dc.date.accessioned2021-01-28T11:09:01Z
dc.date.available2021-01-28T11:09:01Z
dc.date.created2015-08-24
dc.date.issued2015-08-31
dc.description.abstractBlue copper proteins (BCPs) are small and generally soluble copper-containing proteins which participate in monoelectron transfer processes in biological systems. An overview of their electronic and tertiary structure is detailed here. The well-established entatic/rack-induced mechanism is explained by comparing thermodynamic parameters between the folded (tense) and the unfolded (relaxed) forms of the BCP rusticyanin. Recently, NMR solution data have shown that the active sites of BCPs in absence of the metal ion, i.e. in the apoforms, are flexible in the micro-to-second timescale. The rigidity proposed by the entatic/rack-induced mechanism is an imperative for the holoprotein to perform electron transfer; while the flexibility of the apocupredoxin is necessary to uptake the metal ion from the metallochaperones. These apparently contradictory requirements are discussed in the present work. Finally, the role of azurin and some peptides derived from it in anticancer therapy are also described.es
dc.formatapplication/pdfes
dc.format.extent46es
dc.identifier.citationArchives of Biochemistry and Biophysics, 584, 2015, 134-148
dc.identifier.doihttp://dx.doi.org/10.1016/j.abb.2015.08.020
dc.identifier.issn0003-9861
dc.identifier.urihttp://hdl.handle.net/10201/101944
dc.languageenges
dc.relationSpanish Ministerio de Economía y Competitividad and FEDER (Project SAF2011-26611) y Fundación Séneca de la Región de Murcia (Project 15354/PI/10)es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0003986115300461?via%3Dihubes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectBlue copper proteinses
dc.subjectazurines
dc.subjectrusticyanines
dc.subjectrack/entatices
dc.subjectcancer therapyes
dc.subject.otherCDU::5 - Ciencias puras y naturales::54 - Química::546 - Química inorgánicaes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísicaes
dc.titleBlue Copper Proteins: A rigid machine for efficient electron transfer, a flexible device for metal uptakees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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