Publication: Heme oxygenase-1 and cardiovascular disease
Authors
Immenschuh, S. ; Schröder, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Heme oxygenase (HO)-1 is the inducible
isoform of the first and rate-controlling enzyme of heme
degradation. HO-1 is up-regulated by a host of oxidative
stress stimuli and has potent cytoprotective and antiinflammatory
functions via decreasing tissue levels of
the prooxidant heme along with production of bilirubin
and the signaling gas carbon monoxide. This review
deals with recent findings that highlight the emerging
significance of HO-1 in cardiovascular disease.
Evidence is presented on how heme and various
oxidative stress stimuli may cause endothelial cell
dysfunction and how HO-1 may counteract the
detrimental effects of oxidative stress in the
endothelium. Recent advances in the understanding of
the role of endothelial HO-1 for the regulation of the
inflammatory response are summarized, including the
modulation of leukocyte recruitment and transmigration
through the endothelial barrier. Furthermore,
experimental evidence from various cell culture and
animal models is discussed which suggests an
association of HO-1 with the complex sequence of
events that cause atherosclerosis. In the second part of
the review we present potential strategies that apply HO-
1 as a therapeutic target in the treatment of
cardiovascular disease. Specific inducers of HO-activity which may ultimately lead to the development of
clinically relevant pharmacological applications are
introduced.
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