Publication: Effects of a-isoproterenol on denervation atrophy in orbicularis oculi muscle fibers
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Date
1998
Authors
Ishii, K. ; Sowaz, K. ; Zhai, W.G. ; Akita, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effect of the B-adrenoceptor agonist
isoproterenol on the denervated orbicularis oculi muscle
was studied. We cut the facial nerve on the right side of
eight rats and injected isoproterenol (5 mglkg) into four
rats every day. The animals were sacrificed after three
weeks, and small pieces of the orbicularis oculi muscle
were removed. Muscle fibers were separated into single
fibers. Cytochrome oxidase enzyme staining was
applied, and density of cytochrome oxidase enzyme
product and diameter of individual muscle fibers were
analyzed by computer. Some of the muscle fibers were
observed under electron microscopy. The results showed
that diameter and cytochrome oxidase enzyme activity
of the orbicularis oculi muscle decreased by denervation,
otherwise, it increased to near the normal level by
administration of isoproterenol. Electron microscopic
observation showed that the myosion filaments became
thin and their arrangement were disordered by
denervation and their findings recovered to be almost
normal by isoproterenol administration. We concluded
that isoproterenol could prevent the orbicularis oculi
muscle from atrophying which caused by denervation.
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