Publication:
Unexpected exacerbation of neuroinflammatory response after a combined therapy in old parkinsonian mice

Simple item page
dc.contributor.authorGil Martínez, Ana Luisa
dc.contributor.authorCuenca Bermejo, Lorena
dc.contributor.authorEstrada, Cristina
dc.contributor.authorSánchez Rodrigo, Consuelo
dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorHerrero Ezquerro, María Trinidad
dc.contributor.departmentAnatomía Humana y Psicobiología
dc.contributor.departmentIngeniería de la Información y las Comunicaciones
dc.contributor.otherFacultades de la UMU::Facultad de Medicina
dc.date.accessioned2026-02-24T12:11:12Z
dc.date.available2026-02-24T12:11:12Z
dc.date.copyright© 2018 Gil-Martínez, Cuenca, Estrada, Sánchez-Rodrigo, Fernández-Villalba and Herrero.
dc.date.issued2018-11-30
dc.description.abstractThe design of therapeutic strategies that focus on the repositioning of anti-inflammatory and antioxidant drugs are a great bet to slow down the progression of neurodegenerative disorders. Despite the fact that Parkinson’s disease (PD) is an age-related pathology, almost all experimental studies are carried out in young animals. Here, we evaluated the possible neuroprotective effect of the combination of the antioxidant N-acetylcysteine (NAC) and the anti-inflammatory HA-1077 in aged 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice (C57BL/6 mice, 20 months old), whose individual treatment has been shown to have neuroprotective effects in this Parkinsonism model. Interestingly, NAC+HA-1077-based treatment produced a significant increase in dopaminergic neuronal death accompanied by an increase in microglial and astroglial activation in the Substantia Nigra pars compacta (SNpc) and striatum of old-Parkinsonian mice compared to their control group. The astroglial response was also explored by co-immunostaining for GFAP and S100b together with p-JNK and it was found to be particularly exacerbated in the MPTP+NAC+HA-1077 group. The unexpected toxic effects found in the combined use of NAC and HA-1077 in old-Parkinsonian mice highlight the importance of taking into account that in elderly Parkinsonian patients the combination of some drugs (most of them used for other different age-related alterations) can have side effects that may result in the exacerbation of the neurodegenerative process.
dc.formatapplication/pdf
dc.format.extent15
dc.identifier.citationFront. Cell. Neurosci., 30 November 2018, Sec. Cellular Neurophysiology, Volume 12 - 2018
dc.identifier.doihttps://doi.org/10.3389/fncel.2018.00451
dc.identifier.eissn1662-5102
dc.identifier.urihttp://hdl.handle.net/10201/212101
dc.languageeng
dc.publisherFrontiers Media
dc.relationSpanish Ministry of Science and Innovation – FIS PI13/01293 Fundación Séneca (Region of Murcia, Spain) – 19540/PI/14 European Commission – Seventh Framework Programme (FP7/2007–2013), Innovative Medicines Initiative – Grant Agreement No. 115009
dc.relation.publisherversionhttps://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00451/full#h7
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDrug repositioning
dc.subjectParkinsonism
dc.subjectGlia
dc.subjectNeuroinflammation
dc.subjectAging
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleUnexpected exacerbation of neuroinflammatory response after a combined therapy in old parkinsonian mice
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublication848746a7-05ac-4d08-82cb-e6a80680c24f
relation.isAuthorOfPublication80cb2f28-f9ff-4190-8ac0-a4773288c0d3
relation.isAuthorOfPublication072da45c-404e-4559-a637-6e8df94220c7
relation.isAuthorOfPublication9bbe7af5-429b-4029-b621-0399a6838322
relation.isAuthorOfPublication.latestForDiscovery848746a7-05ac-4d08-82cb-e6a80680c24f
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
fncel-12-00451.pdf
Size:
8.86 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos