Publication:
Potential role of NDRG2 in reprogramming cancer metabolism and epithelial-to-mesenchymal transition

Simple item page
dc.contributor.authorChen, Xiang Liu
dc.contributor.authorLei, Lan
dc.contributor.authorHong, Lian Lian
dc.contributor.authorLing, Zhi Qiang
dc.date.accessioned2022-05-05T11:34:55Z
dc.date.available2022-05-05T11:34:55Z
dc.date.issued2018
dc.description.abstractEpithelial-to-mesenchymal transition (EMT) allows a cell with epithelial characteristics to transdifferentiate into a cell with mesenchymal characteristics, which is recognized as a key priming event for the initiation and evolvement of cancer metastasis. Accumulating data has shown that aberrant cancer metabolism contributes to the execution of EMT and cancer metastasis through multiple pathological pathways. Recently, the N-MYC downstream-regulated gene 2 (NDRG2), as a tumor suppressor and metabolism-related gene in various cancers, has been widely noted. NDGR2 is associated with energy metabolism, especially glycose metabolism. Hence, we propose a hypothesis that EMT is repressed by NDRG2 via cancer metabolic reprogramming, and summarize the pathological processes and molecular pathways related to the regulation of NDRG2.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology, Vol.33, nÂş7, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-957
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/119610
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNDRG2 (N-MYC downstream-regulated gene 2)es
dc.subjectTumor suppressor genees
dc.subjectEMT (Epithelial-tomesenchymal transition)es
dc.subjectMetastasises
dc.subjectMetabolic reprogramminges
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titlePotential role of NDRG2 in reprogramming cancer metabolism and epithelial-to-mesenchymal transitiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Chen-33-655-663-2018.pdf
Size:
2.42 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.33, nÂş7 (2018)