Publication: Early embryonic development in the rat following in utero exposure to alcohol and caffeine
Authors
Ross, C.P. ; Persaud, T.V.N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The influence of both alcohol and caffeine
on early embryonic development was investigated in
pregnant rats. Compared to the corresponding controls,
a high incidence of resorptions and abnormal embryos
was induced following treatment of the animals with
alcohol (0.015 ml/g body weight, 12.5% v/v, ¡.p.) on
gestational days 6 through 12 and with caffeine (25 mg/kg
body weight, ¡.v.) on gestational day 10. In addition,
embryonic growth was severely affected. Reduction of
placental blood circulation and impairment of cellular
proliferation may account for the observed deleterious
effects on the embryo.
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Citation
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