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Overexpression of lactate dehydrogenase A in cholangiocarcinoma is correlated with poor prognosis

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dc.contributor.authorThonsri, Unchalee
dc.contributor.authorSeubwai, Wunchana
dc.contributor.authorWaraasawapati, Sakda
dc.contributor.authorSawanyawisuth, Kanlayanee
dc.contributor.authorVaeteewoottacharn, Kulthida
dc.contributor.authorBoonmars, Thidarat
dc.contributor.authorCha’on, Ubon
dc.date.accessioned2022-02-22T09:26:51Z
dc.date.available2022-02-22T09:26:51Z
dc.date.issued2017
dc.description.abstractLactate dehydrogenase A (LDHA), a key metabolic enzyme, plays a crucial role in the final step of anaerobic glycolysis. Overexpression of LDHA is observed in many human malignancies in association with tumor progression. The purpose of this study was to investigate LDHA expression pattern during carcinogenesis, its clinico-pathological association, and evaluate the prognostic value of LDHA in CCA patients. LDHA expression was investigated using immunohistochemistry technique in both hamster- (n=60) and human-CCA tissues (n=82). Plasma LDH from healthy control (n=40) and CCA patients (n=29) were determined using an enzymatic based assay. The association of LDHA expression with clinicopathological findings and prognostic value were evaluated by statistical analysis. In the CCA hamster model, an increase of LDHA expression was associated with the progression of CCA-genesis. Higher LDHA overexpression was associated with shorter survival of CCA patients. Multivariate analysis indicated that LDHA expression including histological type were independent prognostic risk factor of patient’s survival. However, there was no difference in plasma LDH level between CCA patients and healthy controls. LDHA expression is involved in cholangio-carcinogenesis. Overexpression of LDHA can be a marker of poor prognosis in CCA patients and it might be a potential target for CCA treatment.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.32, nº5, (2017)
dc.identifier.doiDOI: 10.14670/HH-819
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/117225
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCholangiocarcinomaes
dc.subjectLactate dehydrogenase Aes
dc.subjectCarcinogenesises
dc.subjectCancer metabolismes
dc.subjectPoor prognosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleOverexpression of lactate dehydrogenase A in cholangiocarcinoma is correlated with poor prognosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nº5 (2017)