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Epidemiology, species dsitribution and in vitro antifungal susceptibility of fungemia in a Spanish multicenter prospective survey

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dc.contributor.authorPemán, Javier
dc.contributor.authorCantón, Emilia
dc.contributor.authorQuindós, Guillermo
dc.contributor.authorEraso, Elena
dc.contributor.authorAlcoba, Julia
dc.contributor.authorGuinea, Jesús
dc.contributor.authorMerino, Paloma
dc.contributor.authorRuiz-Pérez de Pipaon, María Teresa
dc.contributor.authorPérez del Molino, Luisa
dc.contributor.authorLinares-Sicilia, María José
dc.contributor.authorMarco, Francesc
dc.contributor.authorGarcía, Julio
dc.contributor.authorRoselló, Eva María
dc.contributor.authorGómez-G-de-la-Pedrosa, Elia
dc.contributor.authorBorrell, Nuria
dc.contributor.authorPorras, Aurelio
dc.contributor.authorYagüe, Genoveva
dc.contributor.departmentGenética y Microbiología
dc.date.accessioned2024-02-06T07:57:59Z
dc.date.available2024-02-06T07:57:59Z
dc.date.issued2012-05
dc.description.abstractObjectives: To update the knowledge of the epidemiology of fungaemia episodes in Spain, the species implicated and their in vitro antifungal susceptibilities. Methods: Episodes were identified prospectively over 13 months at 44 hospitals. Molecular methods were used to determine the cryptic species inside the Candida parapsilosis and Candida glabrata complexes. Susceptibility to amphotericin B, anidulafungin, caspofungin, fluconazole, flucytosine, itraconazole, micafungin, posaconazole and voriconazole was determined by a microdilution colorimetric method. New species-specific clinical breakpoints (SSCBPs) for echinocandins, fluconazole and voriconazole were applied. Results: The incidence of the 1357 fungaemia episodes evaluated was 0.92 per 1000 admissions. The incidence of Candida albicans fungaemia was the highest (0.41 episodes/1000 admissions), followed by Candida parapsilosis sensu stricto (0.22). Candida orthopsilosis was the fifth cause of fungaemia (0.02), outnumbered by Candida glabrata and Candida tropicalis. Interestingly, the incidence of fungaemia by C. parapsilosis was 11 and 74 times higher than that by C. orthopsilosis and Candida metapsilosis, respectively. Neither Candida nivariensis nor Candida bracarensis was isolated. Fungaemia was more common in non-intensive care unit settings (65.2%) and among elderly patients (46.4%), mixed fungaemia being incidental (1.5%). Overall susceptibility rates were 77.6% for itraconazole, 91.9% for fluconazole and 96.5%-99.8% for the other agents. Important resistance rates were only observed in C. glabrata for itraconazole (24.1%) and posaconazole (14.5%), and in Candida krusei for itraconazole (81.5%). Conclusions: Fungaemia is more common in non-critical patients. C. albicans is the most common species, followed by C. parapsilosis and C. glabrata. Nearly 90% of yeasts are susceptible to all antifungal agents tested. Resistance rates change moderately when applying the new SSCBPs.es
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dc.format.extent6es
dc.identifier.citationJournal of Antimicrobial Chemotherapy, 2012 May;67(5):1181-1187.
dc.identifier.doihttps://doi.org/10.1093/jac/dks019.
dc.identifier.issnPrint: 0305-7453
dc.identifier.issnElectronic: 1460-2091
dc.identifier.urihttp://hdl.handle.net/10201/138688
dc.languageenges
dc.relation"Sin financiación externa a la Universidad".es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectFungemiaes
dc.subjectEpidemiologiaes
dc.subjectSensibilidades
dc.subjectEspecieses
dc.subjectEspañaes
dc.titleEpidemiology, species dsitribution and in vitro antifungal susceptibility of fungemia in a Spanish multicenter prospective surveyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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