Publication: Protein kinase CK2 signal in neoplasia
Authors
Tawfic, S. ; Yu, S. ; Wang, H. ; Faust, R. ; Davis, A. ; Ahmed, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Protein kinase CK2 (previously known as
casein kinase 11) is a protein serinelthreonine kinase that
has been implicated in cell growth and proliferation. The
focus of this review is on the apparent role of CK2 in
cancer. Studies from severa1 laboratories have shown a
dysregulated expression of the kinase in tumors. Nuclear
matrix and chromatin appear to be key sites for signaling
of the CK2 activity in relation to cell growth. Severa1
types of growth stimuli produce a common downstream
response in CK2 by enhancing its nuclear shuttling. The
neoplastic change is also associated with changes in
intracellular localization of the kinase so that a higher
nuclear localization is obsewed in tumor cells compared
with normal cells. Experimental studies suggest that
dysregulated expression of the a subunit of CK2 imparts
an oncogenic potential in the cells such that in
cooperation with certain oncogenes it produces a
profound enhancement of the tumor phenotype. Recent
studies have provided evidence that overexpression of
CK2 in tumor cells is not simply a reflection of tumor
cell proliferation alone but additionally may reflect the
pathobiological characteristics of the tumor. Of
considerable interest is the possibility that CK2
dysregulation in tumors may influence the apoptotic
activity in those cells. Approaches to interfering with the
CK2 signal may provide a useful means for inducing
tumor cell death.
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