Nerve-Langerhans cell interactions in diabetes and aging

Doss, Argenia L.N.; Smith, Peter G.

Publication:
Nerve-Langerhans cell interactions in diabetes and aging

dc.contributor.author	Doss, Argenia L.N.
dc.contributor.author	Smith, Peter G.
dc.date.accessioned	2017-11-09T16:25:33Z
dc.date.available	2017-11-09T16:25:33Z
dc.date.issued	2012
dc.description.abstract	Cutaneous infections are a leading cause of hospitalization of diabetic patients. Langerhans cells (LCs) are antigen-presenting cutaneous dendritic cells that protect against infections, and effects of diabetes and aging on these cells are unclear. We examined LCs in footpads of rats with streptozotocin-induced diabetes at 3 months of age following 4 weeks of diabetes, and at 6 months following 16 weeks of diabetes. Immunostaining of LCs using the selective marker protein langerin showed cutaneous LC composition increased between 3 and 6 months of age owing to increased LC numbers and size in control rats. In diabetic rats, LC numbers increased with age but, unlike 6 month old controls, cell size did not, suggesting that diabetes impairs the increase in cell size that is a hallmark of LC maturation. Diabetes reduced LC numbers after 4 weeks and numbers and sizes following 16 weeks. We examined the relation between LC and innervation and found that, while axon density decreased with aging, it was not affected by 16 weeks of diabetes. However, LCs expressing the neuronal marker PGP9.5 represented a source of error in axonal counts. These findings support the hypothesis that diabetes substantially impacts LC proliferation and maturation independent of effects on cutaneous innervation. Accordingly, the interactions of diabetes and aging on LCs may be important factors in predisposing diabetic patients to cutaneous ulcers and infections.	es
dc.format	application/pdf	es
dc.format.extent	10	es
dc.identifier.citation	Histology and histopathology, Vol. 27, n.º 12 (2012)
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/54476
dc.language	eng	es
dc.publisher	F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Langerhans cells	es
dc.subject	Diabetes	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.4 - Patología del sistema linfático, órganos hematopoyéticos, endocrinos	es
dc.title	Nerve-Langerhans cell interactions in diabetes and aging	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es