Publication: Vascular endothelial growth factor (VEGF),
transforming growth factor-ß (TGFß), and interleukin-6
(IL-6) in experimental herpesvirus retinopathy:
association with inflammation and viral infection
Loading...
Date
2001
Authors
Vinores, S. A. ; Derevjanik, N. L. ; Shi, A. ; Vinores, M. A. ; Klein, D. A. ; Whittum Hudson, J. A.
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Ex pe rime nt a l he rpesv iru s retin opa th y
prese nts a uniqu e model of a transient infl ammatory
response in the virus-injected eye and subsequent acute
retin al nec rosis a nd c hr o ni c infl amm ati o n in th e
co nt ra late ral eye . For 6 days after in fec ti on, VEG F.
TGH \, a nd T GF13 2 we re assoc ia ted o nl y w ith
infl ammatory cells in the injected eye. By 6 days (after
viral anti ge ns we re no longe r detected), VEG F and
TGF132 we re upregul ated in retinas of injected eyes until
8- 10 days. In co ntr alate ra l eyes, VEG F was first
demonstrated in th e re tin a at 6-7 days (pri or to th e
appea rance of vira l antige ns) and TGF13 2 at 7-8 days.
Staining fo r these factors was also evident around areas
of necrosis. The VEGF receptor, fit-I , was associated
with ganglion cells and the inner nuclear laye r of normal
and ex perimental mi ce and it was also demonstrated
around areas of necrosis. Another VEG F receptor, flk-] ,
was loca li zed to MUlle r ce ll processes and th e oute r
plex ifo rm layer in no rm al and ex pe rime nta l mi ce .
Coin cident with VEGF upregul ation in the retinas of
herpesvirus-l injected mice, there was increased fl k-1 in
ganglion ce lls and the inner and out er nuclear laye rs. IL6 was assoc iated with Mull er ce ll endfeet in normal
mice. Following unilateral intraocular inocul ation, IL-6
sp read alo ng th e Miill e r ce ll processes and some
astrocytes demonstra ted IL-6 in both eyes at 6-8 days.
T he pr ese nt stu dy demo nstr ates that intr aoc ul a r
inocul ation of herpesvirus is suffi cient to induce VEGF,
flk-l , TGFI32, and IL-6 in the retin as of inj ected and
contralateral eyes. Furth er investigation of common
signaling pathways fo r these fac tors during responses to
viral in fect ion and th e deve lopme nt of ac ute ret in al
necrosis could prov ide in formation use ful fo r therapeutic
intervention in human herpesviru retinopathy.
publication.page.subject
Citation
Histology and histopathology, Vol. 16, nº 4 (2001)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/