Publication: Analysis of allogenic lymphocytes in rat thymus following sublethal irradiation
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Date
1997
Authors
Ohba, Y. ; Fujikura, Y. ; Sawada, T. ; Tokuda, N. ; Morimatsu, M. ; Fukumoto, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of allogeneic lymphocytes on the
rat thymus following sublethal irradiation were
investigated using immunofluorescence. The recovery of
thymus weight following irradiation was delayeú in rats
6 days after receiving lymphocytes compared to
controls. Allogeneic cells forming colonies were
detected by immunofluorescence in both the cortex and
medulla of the host thymus, most frequently on day 15
when an appropriate number (3x10~) was injected.
The allogeneic cells detected in the host thymus,
presumably T lymphocytes, appeared to disturb thymic
reconstitution following irradiation.
However, double-immunofluorescence staining
revealed that allogeneic cells did not affect the thymic
stromal microenvironment. Allogeneic cells may have
subsequently affected thyrnic tissue via cytokines.
It is important to investigate not only the character
of allogeneic cells in the host thymus but also the
interactions of donor allogeneic cells, host immature
lymphocytes and thymic epithelial cells because of the
possibility that these allogeneic cells in the host thymus
could prevent the rejection of allogeneic transplants.
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