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Octodon degus: a natural model of multimorbidity for ageing research

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dc.contributor.authorCuenca Bermejo, Lorena
dc.contributor.authorPizzichini, Elisa
dc.contributor.authorGonzález Cuello, Ana María
dc.contributor.authorDe Stefano, María Egle
dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorHerrero Ezquerro, María Trinidad
dc.contributor.departmentEnfermería
dc.date.accessioned2024-02-09T09:16:37Z
dc.date.available2024-02-09T09:16:37Z
dc.date.copyright© 2020 Elsevier B.V.
dc.date.issued2020-12
dc.description.abstractIntegrating the multifactorial processes co-occurring in both physiological and pathological human conditions still remains one of the main challenges in translational investigation. Moreover, the impact of age-associated disorders has increased, which underlines the urgent need to find a feasible model that could help in the development of successful therapies. In this sense, the Octodon degus has been indicated as a 'natural' model in many biomedical areas, especially in ageing. This rodent shows complex social interactions and high sensitiveness to early-stressful events, which have been used to investigate neurodevelopmental processes. Interestingly, a high genetic similarity with some key proteins implicated in human diseases, such as apolipoprotein-E, β-amyloid or insulin, has been demonstrated. On the other hand, the fact that this animal is diurnal has provided important contribution in the field of circadian biology. Concerning age-related diseases, this rodent could be a good model of multimorbidity since it naturally develops cognitive decline, neurodegenerative histopathological hallmarks, visual degeneration, type II diabetes, endocrinological and metabolic dysfunctions, neoplasias and kidneys alterations. In this review we have collected and summarized the studies performed on the Octodon degus through the years that support its use as a model for biomedical research, with a special focus on ageing.es
dc.formatapplication/pdfes
dc.format.extent18es
dc.identifier.doihttps://doi.org/10.1016/j.arr.2020.101204
dc.identifier.urihttp://hdl.handle.net/10201/139064
dc.languageenges
dc.publisherElsevier. Science Directes
dc.relationThis research was supported by Fundaci´on S´eneca (19540/PI/14). LCB is granted by the Spanish Ministry of Science, Innovation and Universities (FPU 18/02549), and PE by the “Torno Subito”, Programme promoted by the Regione Lazio and managed by DiSCo Lazio (1912116092019).es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAgeinges
dc.subjectNeuroscienceses
dc.subjectMultimorbidityes
dc.subjectBiomedicinees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::614 - Higiene y salud pública. Contaminación. Prevención de accidentes. Enfermeríaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiologíaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nerviosoes
dc.titleOctodon degus: a natural model of multimorbidity for ageing researches
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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relation.isAuthorOfPublication9bbe7af5-429b-4029-b621-0399a6838322
relation.isAuthorOfPublication.latestForDiscovery9bbe7af5-429b-4029-b621-0399a6838322
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