Publication: Basigin (CD147): a multifunctional transmembrane protein involved in reproduction,
neural function, inflammation and tumor invasion
Authors
Muramatsu, T. ; Miyauchi, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Basigin (Bsg) is a transmembrane
glycoprotein with two immunoglobulin-like domains,
and forms a family with embigin and neuroplastin. In
these proteins a conserved glutamic acid is present in the
middle for the transmembrane domain. Bsg is also called
CD147 and EMMPRIN, and the symbol for the human
basigin gene is BSG. BSG is located in chromosome 19
band p13. 3. Knockout mice deficient in the Bsg gene
are sterile and show various neurological abnormalities.
Bsg-deficient embryos are also difficult to implant. Bsg
has been found to participate in the cell-surface
orientation of monocarboxylic acid transporters (MCTs)
to the plasma membrane. Dysfunction of the retina in
Bsg-deficient mice is ascribed to the failure of plasma
membrane integration of MCTs in the tissue. Bsg is also
involved in inflammatory processes and is proposed to
be a receptor of cyclophilin A; it is also likely to
participate in HIV infection. Bsg in tumor cells triggers
the production or release of matrix metalloproteinases in
the surrounding mesenchymal cells and tumor cells,
thereby contributing to tumor invasion. Furthermore, the
association of Bsg with integrins might be important in
signaling through Bsg.
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