Publication: Ultrastructural changes in the synovial membrane
in experimentally-induced osteoarthritis
of rabbit knee joint
Authors
Vasilev, V. ; Merker, H. J. ; Vidinov, N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Rabbit knee joint osteoarthritis was
induced by intraarticular injections of a 10% sterile
NaCl solution. Within 30 days the synovial membrane
had undergone hyperplasia resulting in activated
synovial fibroblasts. Transitional forms of synoviocytes
as well as activated synovial macrophages were a very
common finding. At 60 days a thickening of the
synovial intima was perceptible. Most of the
synoviocytes were of the fibroblast type. Transitional
cell forms abounded. An increase in collagen fibres
and capillaries of the fenestrated type occurred in the
intercellular spaces. In the deep layer collagen bundles
had formed between which activated fibroblasts and
macrophages were noticed. The described changes
point to an active participation of the synovial
membrane in the destruction of articular cartilage in
osteoarthritis.
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Citation
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