Publication: An islet of Langerhans located within the epithelium of a human pancreatic duct
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Date
1986
Authors
Swartz, Frank J. ; Carstens, Per H.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
An unusual structure resembling an islet
of Langerhans was described in the pancreatic ductal
epithelium of a presumably normal human male. Further
studies to establish the identities of both islet and duct
were performed. The original hematoxylin and eosin
section served for histological description, as well as for
nuclear volume analysis to characterize levels of beta cell
polyploidy. The section was restained with Gomori's
Chrome Alum Hematoxylin Phloxine to ascertain the
presence of islet-like cells and to quantitate the ratio of
beta- to non-beta cells. The section was then restained by
the Feulgen technique to confirm proportionality between
nuclear volume and DNA content. An apparently normal
islet in the same section served as control. The combined
observations were consistent with the interpretation
that the structure is indeed an islet situated within the
ductal epithelium. The almost complete absence of
polyploid beta cells, however, and the high ratio of nonbeta
cel1s:beta cells suggested that it was a young islet.
A similarly high proportion of non-beta cells in the control
islet, as well as the frequent occurrence of ducts within,
or in close proximity to, other islets, suggested that the
entire islet organ was under some form of proliferative
stimulus at time of resection. Alterations of the ductal
epithelium and the secretory contents suggested that the
duct was also in the process of transformation. Although
the islet had apparently arisen within the ductal epithelium,
the ultimate source of the progenitor cells could not bedetermined from these studies. The relationship of the
ductal islet to other well known forms of islet regeneration
is discussed.
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