Publication: Three types of liver cell dysplasia (LCD) in small cirrhotic nodules are distinguishable by karyometry
and PCNA labelling, and their features resemble
distinct grades of hepatocellular carcinoma
Authors
Zhao, M. ; zhang, N.X. ; Du, Z.Y. ; Laissue, J.A. ; Zimmermann, Astrid
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have studied the occurrence and specific
features of li\er cell dysplasia (LCD) in Chinese patients
showing li\.er cirrhosis with or without hepatocellular
carciiioina (HCC). Three types of LCD (SLCD, LLCDo.
LLCDe) were rnorphologically defined. and these types
were further analyzed using karyoinetry, estiniation of
nucleic acid conteiit and deiisity, and PCNA iinmuiiostaiiiing.
Features found for three types of LCD were
coniparetl with those of normal hepatocytes (NLC).
siinple regei~eratiiig hepatocytes (SRLC), and cells of
HCCs covering different grades. The results show that 1 )
Aaryoinetry arid nucleic acid parameters allow an
objecti\,e separation of LCD types both from NLC aiid
SRLC; 2) karyometric features of LLCDe are most cloile
to those of tiighly differentiated HCCs. whereas nuclear
size nnd chroin~itinc omposition of SLCD closely 1-etlect
those of poorly differentiated HCCs: 3) the frequency of
LCD cluster.; was higher iii cirrhotic livers carrying
HCC. being about douhle for al1 three LCD types: 4) the
h i ~ h e sP~CN A labelling occurred in the small cell group
of LCD (SLCD), still, however, beiiig smaller tlian that
of simple i-egenerating hepatocytes. Based on these
fiiidiiiys i t i \ suggested that, similar tu atypical
adenoinatous hyperplasia, LCDs of distinct inorphotypes
riiay represent precursor lesions for HCC, aiid soine
cellular forms niay mimick cell types known to occur in experiinental carcinogenesis.
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