Publication: The antitumor action of
cannabinoids on glioma tumorigenesis
Authors
Zogopoulos, Panagiotis ; Korkolopoulou, Penelope ; Patsouris, Efstratios ; Theocharis, Stamatios
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
10.14670/HH-30.629
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info:eu-repo/semantics/article
Description
Abstract
Cannabinoids are a class of chemical
compounds with a wide spectrum of pharmacological
effects, mediated by two specific plasma membrane
receptors (CB1 and CB2). Recently, CB1 and CB2
expression levels have been detected in human tumors,
including those of brain. Cannabinoids-endocannabinoids exert anti-inflammatory, anti-proliferative,
anti-invasive, anti-metastatic and pro-apoptotic effects in
different cancer types, both in vitro and in vivo in animal
models, after local or systemic administration. We
present the available experimental and clinical data, to
date, regarding the antitumor action of cannabinoids on
the tumorigenesis of gliomas.
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Citation
Histology and Histopathology, vol. 30, nº 6, (2015)
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